Search results for " Exposome"

showing 3 items of 3 documents

A Critical Review of Statistical Methods for Twin Studies Relating Exposure to Early Life Health Conditions

2021

International audience; When investigating disease etiology, twin data provide a unique opportunity to control for confounding and disentangling the role of the human genome and exposome. However, using appropriate statistical methods is fundamental for exploiting such potential. We aimed to critically review the statistical approaches used in twin studies relating exposure to early life health conditions. We searched PubMed, Scopus, Web of Science, and Embase (2011–2021). We identified 32 studies and nine classes of methods. Five were conditional approaches (within-pair analyses): additive-common-erratic (ACE) models (11 studies), generalized linear mixed models (GLMMs, five studies), gene…

ExposomeComputer scienceHealth Toxicology and MutagenesisInferenceMarginal modelReviewexposomeGeneralized linear mixed modeltwin data03 medical and health sciences0302 clinical medicineDiscriminative modelchildren[STAT.AP] Statistics [stat]/Applications [stat.AP]StatisticsHumans030212 general & internal medicineGeneralized estimating equationchildren Exposome Genome Health Statistical methods Twin data Humans Linear Models Models Statisticalgenome030304 developmental biology0303 health sciences[STAT.AP]Statistics [stat]/Applications [stat.AP]Models StatisticalConfoundingPublic Health Environmental and Occupational HealthRhealthTwin studychildren exposome genome health statistical methods twin data[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologieLinear Modelsstatistical methodsMedicine[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
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Prenatal Exposure to Polybrominated Flame Retardants and Fetal Growth in the INMA Cohort (Spain)

2015

Our aim was to investigate the relation between PBDEs and fetal growth or newborn anthropometry in a Spanish cohort (2003-2008). PBDE congeners (BDE-47, -99, -153, -154, and -209) were determined in serum of 670 mothers at gestational week 12 and in 534 umbilical cord samples. Abdominal circumference (AC), estimated fetal weight (EFW), femur length (FL), and biparietal diameter (BPD) during gestation were measured by ultrasounds. At birth, weight (BW), head circumference (HC), and length (BL) were also measured. We assessed growth in the intervals between 12-20 and 20-34 weeks of gestation and size at birth by standard deviation (SD)-scores adjusted for constitutional characteristics. We co…

Adultmedicine.medical_specialtyFetal monitoring010501 environmental sciences01 natural sciencesUmbilical cordFlame retardantsArticleUltrasonography PrenatalCohort StudiesFetal Development03 medical and health sciences0302 clinical medicinePregnancyBayesian multivariate linear regressionInternal medicinePrenatal exposureHalogenated Diphenyl EthersmedicineFetal growthBody SizeHumansEnvironmental ChemistryPregnancy exposome030212 general & internal medicine0105 earth and related environmental sciencesPregnancyObstetricsbusiness.industryBody WeightInfant NewbornGeneral ChemistryAnthropometrymedicine.disease3. Good healthEndocrinologymedicine.anatomical_structureSpainPrenatal Exposure Delayed EffectsCohortGestationFemalebusinessCohort study
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Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health

2022

Developmental age is particularly vulnerable to impacts of environmental exposures. Until recent years, the field of environment and child health has predominantly relied on the study of single exposure–health effect relationships. The exposome is an emerging concept in epidemiology, encompassing the totality of the exposures experienced by an individual throughout life and their changes over time. This innovative approach provides a risk profile instead of individual predictors. Exposome research may contribute to better understand the complex relationships between environmental exposures and childhood respiratory health, in order to implement prevention strategies and mitigate adverse hea…

childrenrespiratory healthPublic Health Environmental and Occupational HealthHumansenvironmental healthepidemiologychildren environmental health epidemiology exposome respiratory healthEnvironmental ExposureexposomeChildFrontiers in Public Health
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